Missing outcomes in randomized trials: addressing the dilemma. A comparison of the general linear mixed model and repeated measures ANOVA using a dataset with multiple missing data points. Move over ANOVA: progress in analyzing repeated-measures data and its reflection in papers published in the Archives of General Psychiatry.
Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke. Delayed treatment with chondroitinase ABC promotes sensorimotor recovery and plasticity after stroke in aged rats. Sustained sensorimotor impairments after endothelin-1 induced focal cerebral ischemia (stroke) in aged rats. Statistical analysis of behavioural data. Analysis of serial measurements in medical research. Matthews, J.N., Altman, D.G., Campbell, M.J.
Applied Longitudinal Data Analysis (Oxford University Press, 2003). Analysis of longitudinal data: the integration of theoretical model, temporal design, and statistical model. This protocol takes 2 h to carry out.Ĭollins, L.M. An alternative analysis method, such as the use of linear models (with various covariance structures), and analysis using restricted maximum likelihood estimation (to include all available data) can be used to better detect treatment effects. If a few data points are missing, as in this example data set (for example, because of animal dropout), repeated-measures analysis of covariance may fail to detect a treatment effect. We guide readers through the analysis of a real-life data set obtained when testing a therapy for brain injury (stroke) in elderly rats. Here we provide an easy-to-use protocol for the analysis of longitudinal data from animals, and we present a click-by-click guide for performing suitable analyses using the statistical package IBM SPSS Statistics software (SPSS).
Modern analytical methods have advantages over conventional methods (particularly when some data are missing), yet they are not used widely by preclinical researchers. Testing of therapies for disease or injury often involves the analysis of longitudinal data from animals.
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